Wednesday, October 5, 2011

The breakthrough discovery of mouse embryonic stem cell differentiation several years ago showed an important progress in the field of biology and experimental medicine, because it allowed the routine manipulation of the mouse genome. Together with the capability to stimulate genetic alterations, it offered the foundation for establishing an in vitro model of early mammalian growth and shown a presumed new origin of differentiated cell kinds for cell replacement therapy. While embryonic stem cells are already used greatly for producing mouse mutants for over a ten years, their use as a model for developmental biology has been reduced and their use in cell replacement therapy remains a goal for many in the field.